InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dlx5

Summary

InnateDB Gene

IDBG-128250.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlx5

Gene Name

distal-less homeobox 5

Synonyms

AI385752

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029755

Encoded Proteins

IDBP-128252

distal-less homeobox 5

IDBP-787904

distal-less homeobox 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105880:
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:6877805-6882085

Strand

Reverse strand

Band

Transcripts

ENSMUST00000052609	ENSMUSP00000052559
ENSMUST00000142635	ENSMUSP00000138264

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0071837	HMG box domain binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001958	endochondral ossification
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0008283	cell proliferation
GO:0030326	embryonic limb morphogenesis
GO:0030509	BMP signaling pathway
GO:0030855	epithelial cell differentiation
GO:0042472	inner ear morphogenesis
GO:0043583	ear development
GO:0045669	positive regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0060021	palate development
GO:0060166	olfactory pit development
GO:0060322	head development
GO:0060325	face morphogenesis
GO:0060349	bone morphogenesis
GO:0071773	cellular response to BMP stimulus
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105880

View Gene Order

ENSBTAG00000018645

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.4873

RefSeq

NM_010056 NM_198854

OMIM

CCDS

CCDS19905 CCDS59691

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas