Version 5.4
Mus musculus Gene: Chka
Summary
InnateDB Gene IDBG-128410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chka
Gene Name choline kinase alpha
Synonyms Chetk-alpha; Chk; ChoK; CK; CK/EK-alpha; EK; EtnK-alpha
Species Mus musculus
Ensembl Gene ENSMUSG00000024843
Encoded Proteins
IDBP-128412
choline kinase alpha
IDBP-128414
choline kinase alpha
IDBP-540524
choline kinase alpha
IDBP-538633
choline kinase alpha
IDBP-534006
choline kinase alpha
IDBP-538485
choline kinase alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110721:
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3851773-3894369
Strand Forward strand
Band A
Transcripts
ENSMUST00000072055 ENSMUSP00000071933
ENSMUST00000025760 ENSMUSP00000025760
ENSMUST00000128694 ENSMUSP00000119919
ENSMUST00000125411
ENSMUST00000125859
ENSMUST00000154467
ENSMUST00000124219
ENSMUST00000139655 ENSMUSP00000116427
ENSMUST00000125640 ENSMUSP00000119493
ENSMUST00000153343 ENSMUSP00000115861
ENSMUST00000148325
ENSMUST00000146463
ENSMUST00000127544
ENSMUST00000125013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004103 choline kinase activity
GO:0004104 cholinesterase activity
GO:0004305 ethanolamine kinase activity
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0033265 choline binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0016310 phosphorylation
GO:0019695 choline metabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110721
View Gene Order
ENSBTAG00000010304
Not yet available
Pathways
NETPATH
REACTOME
REACT_199009
Synthesis of PE pathway
REACT_207335
Synthesis of PC pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121238
Synthesis of PC pathway
REACT_120919
Synthesis of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 12660
UniGene Mm.225505 Mm.397297 Mm.400757
RefSeq NM_001271496 NM_013490
OMIM
CCDS CCDS29400 CCDS70913
HPRD
IMGT
MGI ID MGI:107760
MGI Symbol Chka
EMBL
GenPept
RNA Seq Atlas 12660

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca