InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Clcn5

Summary

InnateDB Gene

IDBG-128942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clcn5

Gene Name

chloride channel 5

Synonyms

5430408K11Rik; ClC-5; Clc5; D930009B12Rik; DXImx42e; Sfc13; T25545

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004317

Encoded Proteins

IDBP-128944

chloride channel 5

IDBP-248959

chloride channel 5

IDBP-532185

chloride channel 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171365:
This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:7153810-7319358

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000004428	ENSMUSP00000004428
ENSMUST00000115746	ENSMUSP00000111412
ENSMUST00000154382
ENSMUST00000128319	ENSMUSP00000122555
ENSMUST00000132126

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005524	ATP binding
GO:0015297	antiporter activity
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0006821	chloride transport
GO:0006897	endocytosis
GO:0034220	ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171365

View Gene Order

ENSBTAG00000001507

Not yet available

Pathways

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9WVD4

TrEMBL

Q8C6W8

UniProt Splice Variant

Entrez Gene

12728

UniGene

Mm.254370 Mm.440363 Mm.445787 Mm.474200 Mm.482981 Mm.487049

RefSeq

NM_016691 XM_006527562 XM_006527563 NM_001243762

OMIM

CCDS

CCDS29963 CCDS57727

HPRD

IMGT

MGI ID

MGI:99486

MGI Symbol

Clcn5

EMBL

AF134117 AK052990 AL808124

GenPept

AAD28473 BAC35233 CAM15287

RNA Seq Atlas

12728