Version 5.4
Mus musculus Gene: Aip
Summary
InnateDB Gene IDBG-128968.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aip
Gene Name aryl-hydrocarbon receptor-interacting protein
Synonyms AA408703; Ara9; AW476050; D19Bwg1412e; Fkbp16; Xap2
Species Mus musculus
Ensembl Gene ENSMUSG00000024847
Encoded Proteins
IDBP-128970
aryl-hydrocarbon receptor-interacting protein
IDBP-401766
aryl-hydrocarbon receptor-interacting protein
IDBP-401765
aryl-hydrocarbon receptor-interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25911105
[Homo sapiens] AIP is a novel inhibitor of IRF7 and a negative regulator of innate antiviral signalling.
Entrez Gene
Summary This gene encodes an Hsp90-associated protein that is localized to the cytoplasm. The encoded protein interacts with the aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor RET, inhibits AhR ubiquitination, and regulates the intracellular localization of AhR. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4114446-4125858
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025767 ENSMUSP00000025767
ENSMUST00000117831 ENSMUSP00000113807
ENSMUST00000121402 ENSMUSP00000114096
ENSMUST00000127767
ENSMUST00000136043
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0036004 GAF domain binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006626 protein targeting to mitochondrion
GO:0006805 xenobiotic metabolic process
GO:0010738 regulation of protein kinase A signaling
GO:0022417 protein maturation by protein folding
GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110711
View Gene Order
ENSBTAG00000010478
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt O08915
TrEMBL D3YW40
UniProt Splice Variant
Entrez Gene 11632
UniGene Mm.10433
RefSeq NM_016666 XM_006531642 XM_006544890 XM_006544891 NM_001276284
OMIM
CCDS CCDS29415
HPRD
IMGT
MGI ID MGI:109622
MGI Symbol Aip
EMBL AC109138 AK146390 BC075614 U85489
GenPept AAB59009 AAH75614 BAE27133
RNA Seq Atlas 11632

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca