InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cav2

Summary

InnateDB Gene

IDBG-128997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cav2

Gene Name

caveolin 2

Synonyms

AI447843

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000058

Encoded Proteins

IDBP-128999

caveolin 2

IDBP-249607

caveolin 2

IDBP-249609

caveolin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:17281185-17289115

Strand

Forward strand

Band

Transcripts

ENSMUST00000000058	ENSMUSP00000000058
ENSMUST00000115462	ENSMUSP00000111122
ENSMUST00000115459	ENSMUSP00000111119

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding
GO:0031748	D1 dopamine receptor binding
GO:0042803	protein homodimerization activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006897	endocytosis
GO:0006906	vesicle fusion
GO:0007005	mitochondrion organization
GO:0007029	endoplasmic reticulum organization
GO:0007088	regulation of mitosis
GO:0007268	synaptic transmission
GO:0008285	negative regulation of cell proliferation
GO:0016050	vesicle organization
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048278	vesicle docking
GO:0048741	skeletal muscle fiber development
GO:0051259	protein oligomerization
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0070836	caveola assembly

Cellular Component

GO:0000139	Golgi membrane
GO:0002080	acrosomal membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009986	cell surface
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105971

View Gene Order

ENSBTAG00000045584

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04510

Focal adhesion pathway

mmu04144

Endocytosis pathway

mmu05100

Bacterial invasion of epithelial cells pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

hsa04510

Focal adhesion pathway

hsa04144

Endocytosis pathway

hsa05100

Bacterial invasion of epithelial cells pathway

INOH

PID NCI

syndecan_2_pathway

Syndecan-2-mediated signaling events

Cross-References

SwissProt

TrEMBL

D3Z147

UniProt Splice Variant

Entrez Gene

12390

UniGene

Mm.396075 Mm.398071

RefSeq

NM_001277756 NM_016900

OMIM

CCDS

CCDS19923 CCDS71727

HPRD

IMGT

MGI ID

MGI:107571

MGI Symbol

Cav2

EMBL

AC023173

GenPept

RNA Seq Atlas

12390