InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cabyr

Summary

InnateDB Gene

IDBG-129056.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cabyr

Gene Name

calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

Synonyms

1700016C01Rik; 4933421A18Rik; CBP86; FSP-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024430

Encoded Proteins

IDBP-129058

calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

IDBP-248721

calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

IDBP-401764

calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

IDBP-401763

calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

IDBP-531502

calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

IDBP-788270

calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

IDBP-788271

calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154040:
To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:12741324-12755146

Strand

Forward strand

Band

Transcripts

ENSMUST00000080415	ENSMUSP00000079277
ENSMUST00000115857	ENSMUSP00000111523
ENSMUST00000121018	ENSMUSP00000113131
ENSMUST00000119108	ENSMUSP00000113760
ENSMUST00000150758	ENSMUSP00000118330
ENSMUST00000191078	ENSMUSP00000140894
ENSMUST00000186263	ENSMUSP00000140870

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001539	cilium or flagellum-dependent cell motility
GO:0019722	calcium-mediated signaling
GO:0048240	sperm capacitation
GO:0051259	protein oligomerization

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0031514	motile cilium
GO:0035686	sperm fibrous sheath
GO:0097228	sperm principal piece
GO:0097229	sperm end piece

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000154040

View Gene Order

ENSBTAG00000005638

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.179740 Mm.395275

RefSeq

NM_001042418 NM_001042419 NM_001042420 NM_027687 NM_181731 XM_006526247

OMIM

CCDS

CCDS37739 CCDS50223 CCDS50224

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas