Version 5.4
Homo sapiens Gene: CCND2
Summary
InnateDB Gene IDBG-12912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCND2
Gene Name cyclin D2
Synonyms KIAK0002; MPPH3
Species Homo sapiens
Ensembl Gene ENSG00000118971
Encoded Proteins
IDBP-12914
cyclin D2
IDBP-601415
cyclin D2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008]
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:4273772-4305350
Strand Forward strand
Band p13.32
Transcripts
ENST00000261254 ENSP00000261254
ENST00000536537 ENSP00000442807
ENST00000536795
ENST00000541542
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 27 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001934 positive regulation of protein phosphorylation
GO:0007049 cell cycle
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000184
View Gene Order
ENSBTAG00000016649
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_821
Cyclin D associated events in G1 pathway
REACT_1590
G1 Phase pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04510
Focal adhesion pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
il2_stat5pathway
IL2 signaling events mediated by STAT5
Cross-References
SwissProt P30279
TrEMBL
UniProt Splice Variant
Entrez Gene 894
UniGene Hs.376071 Hs.609915 Hs.706154 Hs.706277
RefSeq NM_001759
HUGO HGNC:1583
OMIM 123833
CCDS CCDS8524
HPRD
IMGT
EMBL AF518005 AK291146 BC010958 BC089384 BT019847 CH471116 D13639 M88080 M88081 M88082 M88083 M90813 X68452
GenPept AAA51926 AAA51928 AAH10958 AAH89384 AAM54041 AAV38650 BAA02802 BAF83835 CAA48493 EAW88851
RNA Seq Atlas 894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca