InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trib2

Summary

InnateDB Gene

IDBG-129207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trib2

Gene Name

tribbles homolog 2 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020601

Encoded Proteins

IDBP-129209

tribbles homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22271508

Trib2 expression is induced by Tlr5 stimulation to inhibit NF-kB signalling in epithelial cells.

InnateDB Annotation from Orthologs

Summary

PMID 22271508

[Homo sapiens] TRIB2 expression is induced by TLR5 stimulation to inhibit NF-kB signalling in epithelial cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071575:
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:15791727-15816877

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000020922	ENSMUSP00000020922
ENSMUST00000151100

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004860	protein kinase inhibitor activity
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031625	ubiquitin protein ligase binding
GO:0055106	ubiquitin-protein ligase regulator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043405	regulation of MAP kinase activity
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045081	negative regulation of interleukin-10 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045599	negative regulation of fat cell differentiation
GO:0051443	positive regulation of ubiquitin-protein transferase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000071575

View Gene Order

ENSBTAG00000016045

Not yet available

Cross-References

SwissProt

Q8K4K3

TrEMBL

UniProt Splice Variant

Entrez Gene

217410

UniGene

Mm.266679 Mm.408571 Mm.479444 Mm.490716

RefSeq

NM_144551 XM_006515054 XM_006515055

OMIM

CCDS

CCDS25821

HPRD

IMGT

MGI ID

MGI:2145021

MGI Symbol

Trib2

EMBL

AF358867 AK044747 AK080064 AK082329 AK144192 BC027159 BC034338 BC037387

GenPept

AAH27159 AAH34338 AAH37387 AAM45477 BAC32063 BAC37820 BAC38467 BAE25758

RNA Seq Atlas

217410