Version 5.4
Mus musculus Gene: Syp
Summary
InnateDB Gene IDBG-129240.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Syp
Gene Name synaptophysin
Synonyms A230093K24Rik; AI848995; p38; Syn
Species Mus musculus
Ensembl Gene ENSMUSG00000031144
Encoded Proteins
IDBP-129244
synaptophysin
IDBP-541627
synaptophysin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 7559603
[Homo sapiens] SYP is a protein tyrosine phosphatase that associates with IL6ST and JAK2 in IL-11 signal transduction pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102003:
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:7638471-7653256
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000069520 ENSMUSP00000069429
ENSMUST00000149795
ENSMUST00000128890 ENSMUSP00000118544
ENSMUST00000150572
ENSMUST00000137515
ENSMUST00000134355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0015485 cholesterol binding
GO:0017075 syntaxin-1 binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0042169 SH2 domain binding
GO:0042802 identical protein binding
Biological Process
GO:0006897 endocytosis
GO:0007268 synaptic transmission
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0071310 cellular response to organic substance
GO:2000474 regulation of opioid receptor signaling pathway
Cellular Component
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0030054 cell junction
GO:0030285 integral component of synaptic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043229 intracellular organelle
GO:0043234 protein complex
GO:0044306 neuron projection terminus
GO:0045202 synapse
GO:0048786 presynaptic active zone
GO:0060076 excitatory synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102003
View Gene Order
ENSBTAG00000016096
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 20977
UniGene Mm.223674
RefSeq NM_009305
OMIM
CCDS CCDS29967
HPRD
IMGT
MGI ID MGI:98467
MGI Symbol Syp
EMBL
GenPept
RNA Seq Atlas 20977

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca