Version 5.4
Mus musculus Gene: Ssh3
Summary
InnateDB Gene IDBG-129295.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ssh3
Gene Name slingshot homolog 3 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034616
Encoded Proteins
IDBP-129297
slingshot homolog 3 (Drosophila)
IDBP-253003
slingshot homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172830:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4261668-4269172
Strand Reverse strand
Band A
Transcripts
ENSMUST00000037992 ENSMUSP00000047718
ENSMUST00000113852 ENSMUSP00000109483
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0010591 regulation of lamellipodium assembly
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0050770 regulation of axonogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172830
View Gene Order
ENSBTAG00000031590
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt Q8K330
TrEMBL
UniProt Splice Variant
Entrez Gene 245857
UniGene
RefSeq NM_198113 XM_006531750 XM_006531751 XM_006531748 XM_006531749
OMIM
CCDS CCDS29425
HPRD
IMGT
MGI ID MGI:2683546
MGI Symbol Ssh3
EMBL AB099289 AK149880 BC028922
GenPept AAH28922 BAC97812 BAE29141
RNA Seq Atlas 245857

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca