Mus musculus Gene: Wdr45
Summary
InnateDB Gene IDBG-129365.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr45
Gene Name WD repeat domain 45
Synonyms C79260; DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4
Species Mus musculus
Ensembl Gene ENSMUSG00000039382
Encoded Proteins
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196998:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:7721973-7728201
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000043045 ENSMUSP00000041456
ENSMUST00000115689 ENSMUSP00000111353
ENSMUST00000115688 ENSMUSP00000111352
ENSMUST00000115687 ENSMUSP00000111351
ENSMUST00000116634 ENSMUSP00000112333
ENSMUST00000116633 ENSMUSP00000112332
ENSMUST00000156000 ENSMUSP00000121634
ENSMUST00000131077 ENSMUSP00000117784
ENSMUST00000125991 ENSMUSP00000119766
ENSMUST00000154253 ENSMUSP00000138122
ENSMUST00000148624 ENSMUSP00000122086
ENSMUST00000127847
ENSMUST00000144148 ENSMUSP00000116483
ENSMUST00000155914
ENSMUST00000124707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006914 autophagy
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.305725
RefSeq NM_001290792 NM_001290794 NM_001290795 NM_172372 XM_006527656 XM_006527657 XM_006527658 XM_006527660
OMIM
CCDS CCDS29970 CCDS72331
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas