Version 5.4
Homo sapiens Gene: MGRN1
Summary
InnateDB Gene IDBG-12946.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGRN1
Gene Name mahogunin ring finger 1, E3 ubiquitin protein ligase
Synonyms RNF156
Species Homo sapiens
Ensembl Gene ENSG00000102858
Encoded Proteins
IDBP-12948
mahogunin, ring finger 1
IDBP-230274
mahogunin, ring finger 1
IDBP-367463
mahogunin, ring finger 1
IDBP-592111
mahogunin, ring finger 1
IDBP-746633
IDBP-748528
IDBP-751182
IDBP-745140
IDBP-748145
IDBP-749771
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4616493-4690974
Strand Forward strand
Band p13.3
Transcripts
ENST00000262370 ENSP00000262370
ENST00000399577 ENSP00000382487
ENST00000415496 ENSP00000393311
ENST00000536343 ENSP00000443810
ENST00000587145
ENST00000592256
ENST00000590457
ENST00000591673
ENST00000590790 ENSP00000464811
ENST00000588015
ENST00000588111
ENST00000587747 ENSP00000467414
ENST00000586183 ENSP00000465860
ENST00000588994 ENSP00000468819
ENST00000593224 ENSP00000465249
ENST00000591895 ENSP00000468171
ENST00000585676
ENST00000615397
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006513 protein monoubiquitination
GO:0008152 metabolic process
GO:0008333 endosome to lysosome transport
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022517
View Gene Order
ENSBTAG00000018999
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7ERA1
UniProt Splice Variant
Entrez Gene 23295
UniGene Hs.526494
RefSeq NM_001142289 NM_001142290 NM_001142291 NM_015246 XM_005255217 XM_005255219 XM_005255220 XM_005255221
HUGO HGNC:20254
OMIM 607559
CCDS CCDS42115 CCDS45401 CCDS45402 CCDS59256
HPRD 07397
IMGT
EMBL AC023830
GenPept
RNA Seq Atlas 23295

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca