InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdh2

Summary

InnateDB Gene

IDBG-129545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh2

Gene Name

cadherin 2

Synonyms

CDHN; N-cadherin; Ncad

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024304

Encoded Proteins

IDBP-129547

cadherin 2

IDBP-248733

cadherin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170558:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:16588877-16809246

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025166	ENSMUSP00000025166
ENSMUST00000115850	ENSMUSP00000111516
ENSMUST00000152779

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0045294	alpha-catenin binding
GO:0045295	gamma-catenin binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0016339	calcium-dependent cell-cell adhesion
GO:0016477	cell migration
GO:0043410	positive regulation of MAPK cascade
GO:0048514	blood vessel morphogenesis
GO:0051146	striated muscle cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005916	fascia adherens
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016342	catenin complex
GO:0030027	lamellipodium
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome