InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnd1

Summary

InnateDB Gene

IDBG-129584.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnd1

Gene Name

potassium voltage-gated channel, Shal-related family, member 1

Synonyms

1110037K09Rik; Kca2-1; Kv4.1; mShal1; Shal

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009731

Encoded Proteins

IDBP-129586

potassium voltage-gated channel, Shal-related family, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102057:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle. [provided by RefSeq, Jul 2008]
This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:7822289-7838280

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000009875	ENSMUSP00000009875
ENSMUST00000125440

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000102057

View Gene Order

ENSBTAG00000009024

Not yet available

Pathways

NETPATH

REACTOME

REACT_202800

Potassium Channels pathway

REACT_259290

Neuronal System pathway

REACT_199077

Voltage gated Potassium channels pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

REACT_225032

Neuronal System pathway

REACT_224502

Voltage gated Potassium channels pathway

REACT_212420

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.335968 Mm.488529

RefSeq

NM_008423

OMIM

CCDS

CCDS29974

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas