Mus musculus Gene: Otud5 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||
InnateDB Gene | IDBG-129612.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | Otud5 | ||||||||
Gene Name | OTU domain containing 5 | ||||||||
Synonyms | AA407879; AI553596; BB114028; DUBA; DXImx46e; Sfc7 | ||||||||
Species | Mus musculus | ||||||||
Ensembl Gene | ENSMUSG00000031154 | ||||||||
Encoded Proteins |
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
|
||||||||
Protein Structure | |||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||
InnateDB Annotation from Orthologs | |||||||||
Summary |
[Homo sapiens] OTUD5 is a deubiquitinase that regulates Type I interferon (IFN) production where OTUD5 selectively cleaves the lysine-63-linked polyubiquitin chains on TRAF3, resulting in its dissociation from the downstream signalling complex containing TBK1.
|
||||||||
Entrez Gene | |||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068308:
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] |
||||||||
Gene Information | |||||||||
Type | Protein coding | ||||||||
Genomic Location | Chromosome X:7841364-7876626 | ||||||||
Strand | Forward strand | ||||||||
Band | A1.1 | ||||||||
Transcripts | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
|
||||||||
Gene Ontology | |||||||||
Molecular Function |
|
||||||||
Biological Process |
|
||||||||
Cellular Component |
|
||||||||
Orthologs | |||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||
Pathways | |||||||||
NETPATH | |||||||||
REACTOME |
Innate Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
|
||||||||
KEGG |
RIG-I-like receptor signaling pathway pathway
|
||||||||
INOH | |||||||||
PID NCI | |||||||||
Pathway Predictions based on Human Orthology Data | |||||||||
NETPATH | |||||||||
REACTOME |
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Innate Immune System pathway
Immune System pathway
|
||||||||
KEGG |
RIG-I-like receptor signaling pathway pathway
|
||||||||
INOH | |||||||||
PID NCI | |||||||||
Cross-References | |||||||||
SwissProt | |||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | |||||||||
UniGene | Mm.416357 | ||||||||
RefSeq | NM_001290536 NM_001290537 NM_138604 XM_006527663 XM_006527664 XM_006527665 XM_006527667 XM_006527668 | ||||||||
OMIM | |||||||||
CCDS | CCDS29975 CCDS72335 CCDS72336 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
MGI ID | |||||||||
MGI Symbol | |||||||||
EMBL | |||||||||
GenPept | |||||||||
RNA Seq Atlas | |||||||||