InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mcoln1

Summary

InnateDB Gene

IDBG-129776.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcoln1

Gene Name

mucolipin 1

Synonyms

2210015I05Rik; mucolipidin; TRPML1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004567

Encoded Proteins

IDBP-129778

mucolipin 1

IDBP-539514

mucolipin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090674:
This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:3500457-3515232

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000004683	ENSMUSP00000004683
ENSMUST00000160338	ENSMUSP00000123717
ENSMUST00000162797
ENSMUST00000159808
ENSMUST00000159538
ENSMUST00000161842
ENSMUST00000161705

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005261	cation channel activity
GO:0072345	NAADP-sensitive calcium-release channel activity

Biological Process

GO:0006812	cation transport
GO:0016197	endosomal transport
GO:0051209	release of sequestered calcium ion into cytosol
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane
GO:0043235	receptor complex