InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCT8

Summary

InnateDB Gene

IDBG-1301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCT8

Gene Name

chaperonin containing TCP1, subunit 8 (theta)

Synonyms

C21orf112; Cctq; D21S246; PRED71

Species

Homo sapiens

Ensembl Gene

ENSG00000156261

Encoded Proteins

IDBP-1303

chaperonin containing TCP1, subunit 8 (theta)

IDBP-361487

chaperonin containing TCP1, subunit 8 (theta)

IDBP-361509

chaperonin containing TCP1, subunit 8 (theta)

IDBP-589388

chaperonin containing TCP1, subunit 8 (theta)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:29055805-29073797

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000286788	ENSP00000286788
ENST00000432178	ENSP00000407748
ENST00000431234	ENSP00000416832
ENST00000470450
ENST00000496121
ENST00000480359
ENST00000475205
ENST00000484403
ENST00000481059
ENST00000494296
ENST00000540844	ENSP00000442730

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	111 [view]
Protein-Protein	109 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042623	ATPase activity, coupled
GO:0051082	unfolded protein binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding

Cellular Component

GO:0002199	zona pellucida receptor complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0016235	aggresome
GO:0044297	cell body
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome