InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Asap2

Summary

InnateDB Gene

IDBG-130102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asap2

Gene Name

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052632

Encoded Proteins

IDBP-130104

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

IDBP-130106

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

IDBP-130108

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

IDBP-130719

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151693:
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:21111748-21270171

Strand

Forward strand

Band

A1.2

Transcripts

ENSMUST00000090834	ENSMUSP00000088344
ENSMUST00000064595	ENSMUSP00000063217
ENSMUST00000101562	ENSMUSP00000099098
ENSMUST00000050990	ENSMUSP00000054631

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0008150	biological_process
GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005575	cellular_component
GO:0005886	plasma membrane
GO:0032580	Golgi cisterna membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000151693

View Gene Order

ENSBTAG00000002329

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04666

Fc gamma R-mediated phagocytosis pathway

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04666

Fc gamma R-mediated phagocytosis pathway

hsa04144

Endocytosis pathway

INOH

PID NCI

arf6_traffickingpathway

Arf6 trafficking events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.358946 Mm.487801

RefSeq

NM_001004364 NM_001098168 NM_001135192 XM_006515047 XM_006515048 XM_006515049 XM_006515050

OMIM

CCDS

CCDS49036 CCDS49037 CCDS56832

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas