InnateDB Gene
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IDBG-13012.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AZU1
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Gene Name
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azurocidin 1
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Synonyms
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AZAMP; AZU; CAP37; HBP; HUMAZUR; NAZC
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000172232
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Encoded Proteins
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|
Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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Summary |
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Jul 2008]
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Type |
Protein coding
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Genomic Location
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Chromosome 19:825097-832018
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Strand
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Forward strand
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Band
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p13.3
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
|
Protein-Protein |
7
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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No orthologs found for this gene |
SwissProt
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P20160
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
|
566
|
UniGene
|
Hs.72885
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RefSeq
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NM_001700
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HUGO
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HGNC:913
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OMIM
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162815
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CCDS
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CCDS12044
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HPRD |
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IMGT
|
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EMBL
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AC004799
BC069495
BC093931
BC093933
M96326
X58794
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GenPept
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AAB59353
AAH69495
AAH93931
AAH93933
CAA41601
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RNA Seq Atlas
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566
|
|
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