Version 5.4
Mus musculus Gene: Mgrn1
Summary
InnateDB Gene IDBG-130131.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mgrn1
Gene Name mahogunin, ring finger 1
Synonyms 2610042J20Rik; md; mKIAA0544; nc
Species Mus musculus
Ensembl Gene ENSMUSG00000022517
Encoded Proteins
IDBP-130133
mahogunin, ring finger 1
IDBP-130137
mahogunin, ring finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102858:
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4886100-4938296
Strand Forward strand
Band A1
Transcripts
ENSMUST00000070658 ENSMUSP00000068314
ENSMUST00000023159 ENSMUSP00000023159
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006513 protein monoubiquitination
GO:0008333 endosome to lysosome transport
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102858
View Gene Order
ENSBTAG00000018999
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt Q9D074
TrEMBL
UniProt Splice Variant
Entrez Gene 17237
UniGene Mm.291326
RefSeq NM_001252437 NM_029657
OMIM
CCDS CCDS49751 CCDS57016
HPRD
IMGT
MGI ID MGI:2447670
MGI Symbol Mgrn1
EMBL AK011747 AK034100 AK088533 AK129161 AK150176 AK153407 BC046830
GenPept AAH46830 BAB27816 BAC28587 BAC40408 BAC97971 BAE29360 BAE31967
RNA Seq Atlas 17237

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca