Version 5.4
Mus musculus Gene: Stxbp2
Summary
InnateDB Gene IDBG-130245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stxbp2
Gene Name syntaxin binding protein 2
Synonyms C79054; Munc-18-2; Munc-18b; Munc18b; muSec1; Sxtbp2; Sxtp2; Unc18-2; Unc18b
Species Mus musculus
Ensembl Gene ENSMUSG00000004626
Encoded Proteins
IDBP-130247
syntaxin binding protein 2
IDBP-535079
syntaxin binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076944:
This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:3630955-3643644
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000004745 ENSMUSP00000004745
ENSMUST00000160708 ENSMUSP00000125405
ENSMUST00000162867
ENSMUST00000159911
ENSMUST00000159888
ENSMUST00000162737
ENSMUST00000163044
ENSMUST00000161982
ENSMUST00000162974
ENSMUST00000160435
ENSMUST00000159370
ENSMUST00000159652
ENSMUST00000162047
ENSMUST00000161629
ENSMUST00000162832
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
GO:0030348 syntaxin-3 binding
Biological Process
GO:0001909 leukocyte mediated cytotoxicity
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0043312 neutrophil degranulation
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane
GO:0031201 SNARE complex
GO:0042581 specific granule
GO:0042582 azurophil granule
GO:0044194 cytolytic granule
GO:0070062 extracellular vesicular exosome
GO:0070820 tertiary granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000076944
View Gene Order
ENSBTAG00000009178
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.7247
RefSeq NM_011503 XM_006508742 XM_006508743 XM_006508744 XM_006508745 XM_006508746
OMIM
CCDS CCDS22067
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca