Version 5.4
Mus musculus Gene: Itgb1bp1
Summary
InnateDB Gene IDBG-130281.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgb1bp1
Gene Name integrin beta 1 binding protein 1
Synonyms AI449260; AU019480; Icap1
Species Mus musculus
Ensembl Gene ENSMUSG00000062352
Encoded Proteins
IDBP-130285
integrin beta 1 binding protein 1
IDBP-623656
integrin beta 1 binding protein 1
IDBP-623657
integrin beta 1 binding protein 1
IDBP-623658
integrin beta 1 binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119185:
The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21240825-21286237
Strand Reverse strand
Band A1.3
Transcripts
ENSMUST00000076260 ENSMUSP00000075609
ENSMUST00000172962
ENSMUST00000173729 ENSMUSP00000134627
ENSMUST00000173688 ENSMUSP00000133557
ENSMUST00000172834 ENSMUSP00000134508
ENSMUST00000173614
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005092 GDP-dissociation inhibitor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
Biological Process
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006469 negative regulation of protein kinase activity
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007160 cell-matrix adhesion
GO:0007219 Notch signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010595 positive regulation of endothelial cell migration
GO:0010764 negative regulation of fibroblast migration
GO:0015031 protein transport
GO:0030154 cell differentiation
GO:0031214 biomineral tissue development
GO:0032091 negative regulation of protein binding
GO:0032148 activation of protein kinase B activity
GO:0033622 integrin activation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0035148 tube formation
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0043088 regulation of Cdc42 GTPase activity
GO:0043113 receptor clustering
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050880 regulation of blood vessel size
GO:0051451 myoblast migration
GO:0051496 positive regulation of stress fiber assembly
GO:0051781 positive regulation of cell division
GO:0051894 positive regulation of focal adhesion assembly
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090314 positive regulation of protein targeting to membrane
GO:0090315 negative regulation of protein targeting to membrane
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:2001044 regulation of integrin-mediated signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030027 lamellipodium
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119185
View Gene Order
ENSBTAG00000013063
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.273333
RefSeq NM_008403 XM_006514991
OMIM
CCDS CCDS25833
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca