Version 5.4
Mus musculus Gene: Hyal5
Summary
InnateDB Gene IDBG-130356.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hyal5
Gene Name hyaluronoglucosaminidase 5
Synonyms 4933439A12Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000029678
Encoded Proteins
IDBP-130358
hyaluronoglucosaminidase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106304:
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:24875909-24891805
Strand Forward strand
Band A3.1
Transcripts
ENSMUST00000031689 ENSMUSP00000031689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004415 hyalurononglucosaminidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007341 penetration of zona pellucida
GO:0007342 fusion of sperm to egg plasma membrane
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000106304
View Gene Order
ENSBTAG00000031958
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00531
Glycosaminoglycan degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_163796
Interaction With Cumulus Cells pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
KEGG
hsa00531
Glycosaminoglycan degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.251601
RefSeq NM_028957 XM_006505186 XM_006505187
OMIM
CCDS CCDS19948
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca