Version 5.4
Mus musculus Gene: Pkia
Summary
InnateDB Gene IDBG-130473.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pkia
Gene Name protein kinase inhibitor, alpha
Synonyms AI415001; PKIalpha
Species Mus musculus
Ensembl Gene ENSMUSG00000027499
Encoded Proteins
IDBP-130475
protein kinase inhibitor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171033:
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:7366604-7445366
Strand Forward strand
Band A1
Transcripts
ENSMUST00000028999 ENSMUSP00000028999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004862 cAMP-dependent protein kinase inhibitor activity
GO:0005515 protein binding
GO:0034236 protein kinase A catalytic subunit binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0042308 negative regulation of protein import into nucleus
GO:0043086 negative regulation of catalytic activity
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171033
View Gene Order
ENSBTAG00000008150
Not yet available
Cross-References
SwissProt P63248
TrEMBL
UniProt Splice Variant
Entrez Gene 18767
UniGene Mm.3193 Mm.396663 Mm.472190
RefSeq NM_008862 XM_006530056
OMIM
CCDS CCDS38383
HPRD
IMGT
MGI ID MGI:104747
MGI Symbol Pkia
EMBL AK139347 BC048244 CH466577 M63554
GenPept AAA39940 AAH48244 BAE23970 EDL05208 EDL05209
RNA Seq Atlas 18767

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca