Version 5.4
| Mus musculus Gene: Rnf125 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-130476.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Rnf125 | ||||||||
| Gene Name | ring finger protein 125 | ||||||||
| Synonyms | 4930553F04Rik | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000033107 | ||||||||
| Encoded Proteins |
ring finger protein 125
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] RNF125 is an ubiquitin ligase which negatively regulates RIG-I signalling by conjugating ubiquitin to DDX58 and MDA5 and IPS1, tagging them for proteosomal degradation
[Homo sapiens] RNF125 is inhibited by human Bocavirus protein, VP2, to induce the IFNB signalling pathway.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101695:
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 18:20944625-20983848 | ||||||||
| Strand | Forward strand | ||||||||
| Band | A2 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Innate Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
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| KEGG |
RIG-I-like receptor signaling pathway pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Innate Immune System pathway
Immune System pathway
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| KEGG |
RIG-I-like receptor signaling pathway pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Mm.400478 | ||||||||
| RefSeq | NM_026301 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS29088 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | |||||||||
| MGI Symbol | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||