InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAPK12

Summary

InnateDB Gene

IDBG-13093.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK12

Gene Name

mitogen-activated protein kinase 12

Synonyms

ERK3; ERK6; P38GAMMA; PRKM12; SAPK-3; SAPK3

Species

Homo sapiens

Ensembl Gene

ENSG00000188130

Encoded Proteins

IDBP-13095

mitogen-activated protein kinase 12

IDBP-238840

mitogen-activated protein kinase 12

IDBP-238842

mitogen-activated protein kinase 12

IDBP-811839

mitogen-activated protein kinase 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:50245450-50261825

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000215659	ENSP00000215659
ENST00000395780	ENSP00000379126
ENST00000395778	ENSP00000379124
ENST00000497036
ENST00000488504
ENST00000467891
ENST00000496942
ENST00000482969
ENST00000497738
ENST00000492218
ENST00000622558	ENSP00000479972

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006975	DNA damage induced protein phosphorylation
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0007517	muscle organ development
GO:0018105	peptidyl-serine phosphorylation
GO:0042692	muscle cell differentiation
GO:0045445	myoblast differentiation
GO:0045786	negative regulation of cell cycle
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051149	positive regulation of muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022610

View Gene Order

ENSBTAG00000019574

Not yet available

Pathways

NETPATH

NetPath_6

KitReceptor pathway

NetPath_24

TSLP pathway

REACTOME

REACT_75776

NOD1/2 Signaling Pathway pathway

REACT_12065

p38MAPK events pathway

REACT_12033

Signalling to RAS pathway

REACT_25299

DSCAM interactions pathway

REACT_21402

CDO in myogenesis pathway

REACT_200751

Organelle biogenesis and maintenance pathway

REACT_111045

Developmental Biology pathway

REACT_11061

Signalling by NGF pathway

REACT_111155

Cell-Cell communication pathway

REACT_200686

Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway

REACT_12529

Signaling by VEGF pathway

REACT_200788

Mitochondrial biogenesis pathway

REACT_6802

Innate Immune System pathway

REACT_111102

Signal Transduction pathway

REACT_21303

Myogenesis pathway

REACT_75913

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway

REACT_6900

Immune System pathway

REACT_228166

VEGFA-VEGFR2 Pathway pathway

REACT_12058

Signalling to ERKs pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

KEGG

hsa04912

GnRH signaling pathway pathway

hsa04370

VEGF signaling pathway pathway

hsa04664

Fc epsilon RI signaling pathway pathway

hsa05120

Epithelial cell signaling in Helicobacter pylori infection pathway

hsa04010

MAPK signaling pathway pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04660

T cell receptor signaling pathway pathway

hsa04620

Toll-like receptor signaling pathway pathway

hsa05014

Amyotrophic lateral sclerosis (ALS) pathway

hsa04722

Neurotrophin signaling pathway pathway

hsa04914

Progesterone-mediated oocyte maturation pathway

hsa04622

RIG-I-like receptor signaling pathway pathway

hsa04621

NOD-like receptor signaling pathway pathway

hsa04114

Oocyte meiosis pathway

hsa05140

Leishmaniasis pathway

hsa05142

Chagas disease (American trypanosomiasis) pathway

hsa04380

Osteoclast differentiation pathway

hsa05131

Shigellosis pathway

hsa05145

Toxoplasmosis pathway

hsa05160

Hepatitis C pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

IL-1 signaling pathway pathway

INOH website

Toll-like receptor signaling pathway pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

INOH website

TGF-beta signaling pathway

INOH website

BMP2 signaling pathway

PID NCI

p38gammadeltapathway

Signaling mediated by p38-gamma and p38-delta

rhoa_pathway

RhoA signaling pathway

Cross-References

SwissProt

P53778

TrEMBL

A8MY48 B5MDL5

UniProt Splice Variant

Entrez Gene

6300

UniGene

Hs.432642 Hs.735353

RefSeq

NM_002969

HUGO

HGNC:6874

OMIM

602399

CCDS

CCDS14089

HPRD

IMGT

EMBL

AL022328 BC015741 CH471138 CR456515 U66243 X79483 Y10487

GenPept

AAB40118 AAH15741 CAA55984 CAA71511 CAG30401 EAW73521

RNA Seq Atlas

6300