Version 5.4
Mus musculus Gene: Dtna
Summary
InnateDB Gene IDBG-131149.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dtna
Gene Name dystrobrevin alpha
Synonyms 2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A; Gm19389
Species Mus musculus
Ensembl Gene ENSMUSG00000024302
Encoded Proteins
IDBP-131151
dystrobrevin alpha
IDBP-248767
dystrobrevin alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134769:
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:23415415-23659714
Strand Forward strand
Band A2
Transcripts
ENSMUST00000047954 ENSMUSP00000037475
ENSMUST00000115832 ENSMUSP00000111498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030165 PDZ domain binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0016014 dystrobrevin complex
GO:0030054 cell junction
GO:0030424 axon
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0042383 sarcolemma
GO:0042995 cell projection
GO:0043234 protein complex
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134769
View Gene Order
ENSBTAG00000012307
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.94371
RefSeq NM_001285808 NM_001285810 NM_001285813 NM_001285817 NM_010087 NM_207650 XM_006525614 XM_006525615 XM_006525616 XM_006525624
OMIM
CCDS CCDS29094 CCDS50236
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca