InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Map2k7

Summary

InnateDB Gene

IDBG-131170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map2k7

Gene Name

mitogen-activated protein kinase kinase 7

Synonyms

5930412N11Rik; JNKK 2; Jnkk2; MAPKK 7; Mapkk7; MEK 7; Mek7; Mkk7; Prkmk7; sek2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002948

Encoded Proteins

IDBP-131172

mitogen-activated protein kinase kinase 7

IDBP-131174

mitogen-activated protein kinase kinase 7

IDBP-259045

mitogen-activated protein kinase kinase 7

IDBP-259047

mitogen-activated protein kinase kinase 7

IDBP-259049

mitogen-activated protein kinase kinase 7

IDBP-259051

mitogen-activated protein kinase kinase 7

IDBP-259053

mitogen-activated protein kinase kinase 7

IDBP-537683

mitogen-activated protein kinase kinase 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24651600

[Homo sapiens] Upon viral infection, MAVS recruits MKK7 onto mitochondria, leading to the induction of apoptosis by MAP2K7 activated MAPK9

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076984:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:4238740-4251423

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000003027	ENSMUSP00000003027
ENSMUST00000062686	ENSMUSP00000054512
ENSMUST00000110999	ENSMUSP00000106627
ENSMUST00000110998	ENSMUSP00000106626
ENSMUST00000110996	ENSMUSP00000106624
ENSMUST00000110995	ENSMUSP00000106623
ENSMUST00000110994	ENSMUSP00000106622
ENSMUST00000145165	ENSMUSP00000117418
ENSMUST00000129866
ENSMUST00000129537

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008545	JUN kinase kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043525	positive regulation of neuron apoptotic process
GO:0051403	stress-activated MAPK cascade
GO:0072709	cellular response to sorbitol