InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rrm2

Summary

InnateDB Gene

IDBG-131192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rrm2

Gene Name

ribonucleotide reductase M2

Synonyms

AA407299; R2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020649

Encoded Proteins

IDBP-131194

ribonucleotide reductase M2

IDBP-533254

ribonucleotide reductase M2

IDBP-533316

ribonucleotide reductase M2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171848:
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:24708241-24714146

Strand

Forward strand

Band

A1.3

Transcripts

ENSMUST00000020980	ENSMUSP00000020980
ENSMUST00000147789
ENSMUST00000153058	ENSMUSP00000120893
ENSMUST00000154588	ENSMUSP00000119502

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006260	DNA replication
GO:0009186	deoxyribonucleoside diphosphate metabolic process
GO:0009262	deoxyribonucleotide metabolic process
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0051259	protein oligomerization
GO:0051290	protein heterotetramerization
GO:0055114	oxidation-reduction process