InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Drap1

Summary

InnateDB Gene

IDBG-131547.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Drap1

Gene Name

Dr1 associated protein 1 (negative cofactor 2 alpha)

Synonyms

2310074H19Rik; NC2-alpha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024914

Encoded Proteins

IDBP-131549

Dr1 associated protein 1 (negative cofactor 2 alpha)

IDBP-253380

Dr1 associated protein 1 (negative cofactor 2 alpha)

IDBP-253382

Dr1 associated protein 1 (negative cofactor 2 alpha)

IDBP-537515

Dr1 associated protein 1 (negative cofactor 2 alpha)

IDBP-619841

Dr1 associated protein 1 (negative cofactor 2 alpha)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175550:
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:5422805-5424979

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025853	ENSMUSP00000025853
ENSMUST00000113674	ENSMUSP00000109304
ENSMUST00000113673	ENSMUSP00000109303
ENSMUST00000124478
ENSMUST00000125468
ENSMUST00000148219	ENSMUSP00000121162
ENSMUST00000126908
ENSMUST00000127043
ENSMUST00000136579	ENSMUSP00000133692
ENSMUST00000134697

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity