Version 5.4
Mus musculus Gene: Pex1
Summary
InnateDB Gene IDBG-131610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pex1
Gene Name peroxisomal biogenesis factor 1
Synonyms 5430414H02Rik; E330005K07Rik; ZWS1
Species Mus musculus
Ensembl Gene ENSMUSG00000005907
Encoded Proteins
IDBP-131612
peroxisomal biogenesis factor 1
IDBP-401599
peroxisomal biogenesis factor 1
IDBP-537606
peroxisomal biogenesis factor 1
IDBP-541804
peroxisomal biogenesis factor 1
IDBP-534459
peroxisomal biogenesis factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127980:
This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. [provided by RefSeq, Jul 2008]
This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:3596066-3637232
Strand Forward strand
Band A1
Transcripts
ENSMUST00000006061 ENSMUSP00000006061
ENSMUST00000121291 ENSMUSP00000113304
ENSMUST00000142516 ENSMUSP00000116474
ENSMUST00000123268
ENSMUST00000126545 ENSMUSP00000121813
ENSMUST00000143959
ENSMUST00000143132 ENSMUSP00000116645
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008289 lipid binding
GO:0009378 four-way junction helicase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0032403 protein complex binding
GO:0042623 ATPase activity, coupled
Biological Process
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006625 protein targeting to peroxisome
GO:0006810 transport
GO:0007031 peroxisome organization
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0016558 protein import into peroxisome matrix
GO:0051301 cell division
GO:0060152 microtubule-based peroxisome localization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127980
View Gene Order
ENSBTAG00000024431
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.379196
RefSeq NM_027777 XM_006503605 XM_006503607 XM_006503608
OMIM
CCDS CCDS19065
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca