Version 5.4
Mus musculus Gene: Rsad2
Summary
InnateDB Gene IDBG-131654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rsad2
Gene Name radical S-adenosyl methionine domain containing 2
Synonyms 2510004L01Rik; cig5; Vig1
Species Mus musculus
Ensembl Gene ENSMUSG00000020641
Encoded Proteins
IDBP-131656
radical S-adenosyl methionine domain containing 2
IDBP-542893
radical S-adenosyl methionine domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20308629
[Homo sapiens] RSAD2 (viperin) is an antiviral protein whose expression is highly upregulated during viral infections via IFN-dependent and/or IFN-independent pathways and an IRF1 mediated type I IFN independent mechanism of enhanced RSAD2 expression provides a redundant mechanism to protect cells from viral infections.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134321:
Gene Information
Type Protein coding
Genomic Location Chromosome 12:26442753-26456452
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000020970 ENSMUSP00000020970
ENSMUST00000137792 ENSMUSP00000121791
ENSMUST00000142732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 6 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0043621 protein self-association
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0001503 ossification
GO:0008152 metabolic process
GO:0009615 response to virus
GO:0030278 regulation of ossification
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway
GO:0034165 positive regulation of toll-like receptor 9 signaling pathway
GO:0035710 CD4-positive, alpha-beta T cell activation
GO:0043367 CD4-positive, alpha-beta T cell differentiation
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0050709 negative regulation of protein secretion
GO:0051607 defense response to virus
GO:2000553 positive regulation of T-helper 2 cell cytokine production
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134321
View Gene Order
ENSBTAG00000016061
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24045 Mm.473306
RefSeq NM_021384
OMIM
CCDS CCDS25848
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca