Version 5.4
Mus musculus Gene: Elp2
Summary
InnateDB Gene IDBG-131732.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elp2
Gene Name elongator acetyltransferase complex subunit 2
Synonyms AU023723; Epl2; Statip1; StIP1
Species Mus musculus
Ensembl Gene ENSMUSG00000024271
Encoded Proteins
IDBP-131734
elongation protein 2 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 10954736
[Homo sapiens] ELP2 is a STAT3-interacting protein that regulates cytokine signal transduction and may regulate the activation of STAT3.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134759:
Gene Information
Type Protein coding
Genomic Location Chromosome 18:24603961-24638830
Strand Forward strand
Band A2
Transcripts
ENSMUST00000025120 ENSMUSP00000025120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0061133 endopeptidase activator activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010950 positive regulation of endopeptidase activity
GO:0043248 proteasome assembly
GO:0046425 regulation of JAK-STAT cascade
Cellular Component
GO:0000502 proteasome complex
GO:0005737 cytoplasm
GO:0008023 transcription elongation factor complex
GO:0033588 Elongator holoenzyme complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134759
View Gene Order
ENSBTAG00000018954
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q91WG4
TrEMBL
UniProt Splice Variant
Entrez Gene 58523
UniGene Mm.25298 Mm.400525 Mm.468289
RefSeq NM_021448
OMIM
CCDS CCDS29103
HPRD
IMGT
MGI ID MGI:1889642
MGI Symbol Elp2
EMBL AF291064 AK033246 AK034457 AK050960 AK147826 AK167725 AK167853 AK168370 BC015284 BC051943
GenPept AAG01032 AAH15284 AAH51943 BAC28210 BAC28716 BAC34477 BAE28163 BAE39766 BAE39871 BAE40302
RNA Seq Atlas 58523

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca