Version 5.4
Mus musculus Gene: Sox11
Summary
InnateDB Gene IDBG-131874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sox11
Gene Name SRY-box containing gene 11
Synonyms 1110038H03Rik; 6230403H02Rik; AI836553; end1
Species Mus musculus
Ensembl Gene ENSMUSG00000063632
Encoded Proteins
IDBP-131876
SRY-box containing gene 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176887:
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:27334264-27342574
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000079063 ENSMUSP00000078070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001071 nucleic acid binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001158 enhancer sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001822 kidney development
GO:0001841 neural tube formation
GO:0002089 lens morphogenesis in camera-type eye
GO:0003151 outflow tract morphogenesis
GO:0003211 cardiac ventricle formation
GO:0003357 noradrenergic neuron differentiation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006412 translation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014003 oligodendrocyte development
GO:0014009 glial cell proliferation
GO:0014032 neural crest cell development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0021510 spinal cord development
GO:0021782 glial cell development
GO:0030182 neuron differentiation
GO:0030513 positive regulation of BMP signaling pathway
GO:0035332 positive regulation of hippo signaling cascade
GO:0035914 skeletal muscle cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046887 positive regulation of hormone secretion
GO:0048485 sympathetic nervous system development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050769 positive regulation of neurogenesis
GO:0060022 hard palate development
GO:0060023 soft palate development
GO:0060174 limb bud formation
GO:0060253 negative regulation of glial cell proliferation
GO:0060412 ventricular septum morphogenesis
GO:0060425 lung morphogenesis
GO:0060548 negative regulation of cell death
GO:0060563 neuroepithelial cell differentiation
GO:0061029 eyelid development in camera-type eye
GO:0061053 somite development
GO:0061303 cornea development in camera-type eye
GO:0061386 closure of optic fissure
GO:0072395 signal transduction involved in cell cycle checkpoint
GO:2000648 positive regulation of stem cell proliferation
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2001111 positive regulation of lens epithelial cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000176887
View Gene Order
Cross-References
SwissProt Q7M6Y2
TrEMBL
UniProt Splice Variant
Entrez Gene 20666
UniGene Mm.41702
RefSeq NM_009234
OMIM
CCDS CCDS25849
HPRD
IMGT
MGI ID MGI:98359
MGI Symbol Sox11
EMBL AB108675 AF009414 AK146514 AK165693 BC062095 BK001484 Z18960
GenPept AAB82425 AAH62095 BAC75670 BAE27226 BAE38341 CAA79485 DAA01568
RNA Seq Atlas 20666

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca