Version 5.4
Mus musculus Gene: Akap12
Summary
InnateDB Gene IDBG-131898.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akap12
Gene Name A kinase (PRKA) anchor protein (gravin) 12
Synonyms AI317366; Srcs5; SSeCKS; Tsga12
Species Mus musculus
Ensembl Gene ENSMUSG00000038587
Encoded Proteins
IDBP-131902
A kinase (PRKA) anchor protein (gravin) 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131016:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:4266329-4359468
Strand Forward strand
Band A1
Transcripts
ENSMUST00000045730 ENSMUSP00000035829
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008179 adenylate cyclase binding
GO:0030159 receptor signaling complex scaffold activity
GO:0051018 protein kinase A binding
Biological Process
GO:0006605 protein targeting
GO:0007165 signal transduction
GO:0010739 positive regulation of protein kinase A signaling
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0090036 regulation of protein kinase C signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131016
View Gene Order
ENSBTAG00000014788
Not yet available
Cross-References
SwissProt Q9WTQ5
TrEMBL B2RRE0
UniProt Splice Variant
Entrez Gene 83397
UniGene Mm.27481
RefSeq NM_031185
OMIM
CCDS CCDS56673
HPRD
IMGT
MGI ID MGI:1932576
MGI Symbol Akap12
EMBL AB020886 AB025278 AB051563 AB070852 AB070853 AF326228 AF326230 AK053844 BC042461 BC043939 BC138364 BC138365 CH466562
GenPept AAH42461 AAH43939 AAI38365 AAI38366 AAK16150 AAK16152 BAA76894 BAB72161 BAB72164 BAB72165 BAC35553 BAC66465 EDL03593
RNA Seq Atlas 83397

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca