Mus musculus Gene: Irf5 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-132026.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Irf5 | ||||||||||||||||||||||
Gene Name | interferon regulatory factor 5 | ||||||||||||||||||||||
Synonyms | AW491843; mirf5 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000029771 | ||||||||||||||||||||||
Encoded Proteins |
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
Phosphorylation of Irf5 at ser451 and ser462 is the primary trigger of Irf5 function in nuclear accumulation, transcription and apoptosis. (Demonstrated in human)
Irf5 modulates West Nile virus pathogenesis and host immune responses by shaping the early pro-inflammatory cytokine response in the draining lymph node.
Traf2 mediates proteasome-dependent degradation of Irf5 and Rel as well as regulating macrophage polarization in tumour microenvironment and controlling tumour growth.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] IRF5 is activated by both TBK1 and MYD88 to form a homodimer that binds to and activates transcription of type I interferon and inflammatory cytokine genes.
[Homo sapiens] IRF5 can act as both an activator and a repressor of interferon (IFN) gene induction dependent on the IRF-interacting partner, and may be a part of the regulatory network that ensures timely expression of the immediate early inflammatory genes.
[Homo sapiens] Phosphorylation of IRF5 at ser451 and ser462 is the primary trigger of IRF5 function in nuclear accumulation, transcription and apoptosis.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128604:
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 6:29526625-29541869 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | A3.3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cytokine Signaling in Immune system pathway
Immune System pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
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KEGG |
Toll-like receptor signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Interferon alpha/beta signaling pathway
Interferon gamma signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
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KEGG |
Toll-like receptor signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Direct p53 effectors
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.486450 Mm.490119 Mm.6479 | ||||||||||||||||||||||
RefSeq | NM_001252382 NM_012057 XM_006505094 XM_006505095 XM_006505096 XM_006505097 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19962 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||