Version 5.4
Mus musculus Gene: Amph
Summary
InnateDB Gene IDBG-132340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Amph
Gene Name amphiphysin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021314
Encoded Proteins
IDBP-132342
amphiphysin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078053:
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:18948371-19150913
Strand Forward strand
Band A2
Transcripts
ENSMUST00000003345 ENSMUSP00000003345
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0007612 learning
GO:0048488 synaptic vesicle endocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0031256 leading edge membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078053
View Gene Order
ENSBTAG00000031967
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
erbb1_internalization_pathway
Internalization of ErbB1
Cross-References
SwissProt Q7TQF7
TrEMBL Q80YA2
UniProt Splice Variant
Entrez Gene 218038
UniGene
RefSeq NM_001289546 NM_175007 XM_006516642 XM_006516643
OMIM
CCDS CCDS26258
HPRD
IMGT
MGI ID MGI:103574
MGI Symbol Amph
EMBL BC024817 BC043718 BC054718
GenPept AAH24817 AAH43718 AAH54718
RNA Seq Atlas 218038

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca