Version 5.4
Mus musculus Gene: Ing1
Summary
InnateDB Gene IDBG-132802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ing1
Gene Name inhibitor of growth family, member 1
Synonyms 2610028J21Rik; AA407184; AI875420; mING1h; p33Ing1; p37Ing1b
Species Mus musculus
Ensembl Gene ENSMUSG00000045969
Encoded Proteins
IDBP-132804
inhibitor of growth family, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153487:
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:11556066-11563250
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000054399 ENSMUSP00000062593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
Biological Process
GO:0006606 protein import into nucleus
GO:0007049 cell cycle
GO:0008285 negative regulation of cell proliferation
GO:0010941 regulation of cell death
GO:0016568 chromatin modification
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153487
View Gene Order
ENSBTAG00000025211
Not yet available
Cross-References
SwissProt Q9QXV3
TrEMBL Q3ULE3
UniProt Splice Variant
Entrez Gene 26356
UniGene Mm.25709 Mm.474035
RefSeq NM_011919 XM_006508804
OMIM
CCDS CCDS22097
HPRD
IMGT
MGI ID MGI:1349481
MGI Symbol Ing1
EMBL AF149820 AF177753 AF177755 AF177756 AF177757 AK141466 AK145553 AK157424 BC016573 BC147770 BC147784
GenPept AAF09183 AAF16908 AAF16909 AAF16910 AAF16911 AAH16573 AAI47771 AAI47785 BAE24693 BAE26505 BAE34085
RNA Seq Atlas 26356

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca