Version 5.4
Mus musculus Gene: Cmbl
Summary
InnateDB Gene IDBG-132871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cmbl
Gene Name carboxymethylenebutenolidase-like (Pseudomonas)
Synonyms 2310016A09Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000022235
Encoded Proteins
IDBP-132873
carboxymethylenebutenolidase-like (Pseudomonas)
IDBP-537145
carboxymethylenebutenolidase-like (Pseudomonas)
IDBP-539688
carboxymethylenebutenolidase-like (Pseudomonas)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164237:
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:31568791-31590119
Strand Forward strand
Band B2
Transcripts
ENSMUST00000070918 ENSMUSP00000070314
ENSMUST00000162532 ENSMUSP00000125296
ENSMUST00000161088 ENSMUSP00000125020
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016787 hydrolase activity
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164237
View Gene Order
ENSBTAG00000010801
Not yet available
Cross-References
SwissProt
TrEMBL E0CXT6
UniProt Splice Variant
Entrez Gene 69574
UniGene Mm.28108
RefSeq NM_181588 XM_006520176 XM_006520177
OMIM
CCDS CCDS27410
HPRD
IMGT
MGI ID MGI:1916824
MGI Symbol Cmbl
EMBL AC137842
GenPept
RNA Seq Atlas 69574

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca