Mus musculus Gene: Cops5 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-133028.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Cops5 | ||||||||||||||||||||||
Gene Name | COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) | ||||||||||||||||||||||
Synonyms | AI303502; CSN5; Jab1; Mov34; Sgn5 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000025917 | ||||||||||||||||||||||
Encoded Proteins |
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
Cops5 is required for activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of Nfe2l2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] COPS5 is required for the activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of NFE2L2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis. (Demonstrated in murine model)
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121022:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008] The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 1:10024601-10038168 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 668 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
TGF_beta_Receptor pathway
TNFalpha pathway
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REACTOME | |||||||||||||||||||||||
KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
AP-1 transcription factor network
HIF-1-alpha transcription factor network
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
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Cross-References | |||||||||||||||||||||||
SwissProt | O35864 | ||||||||||||||||||||||
TrEMBL | Q3V0K7 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 26754 | ||||||||||||||||||||||
UniGene | Mm.402384 Mm.474110 | ||||||||||||||||||||||
RefSeq | NM_013715 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS14818 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1349415 | ||||||||||||||||||||||
MGI Symbol | Cops5 | ||||||||||||||||||||||
EMBL | AF065386 AF068223 AK012499 AK133073 AK146271 AK151492 BC046753 U70736 | ||||||||||||||||||||||
GenPept | AAC17179 AAD03470 AAF61318 AAH46753 BAB28282 BAE21497 BAE27030 BAE30445 | ||||||||||||||||||||||
RNA Seq Atlas | 26754 | ||||||||||||||||||||||