Version 5.4
Mus musculus Gene: Adam22
Summary
InnateDB Gene IDBG-133249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adam22
Gene Name a disintegrin and metallopeptidase domain 22
Synonyms 2900022I03Rik; AI854032; MDC2
Species Mus musculus
Ensembl Gene ENSMUSG00000040537
Encoded Proteins
IDBP-133251
a disintegrin and metallopeptidase domain 22
IDBP-133255
a disintegrin and metallopeptidase domain 22
IDBP-133263
a disintegrin and metallopeptidase domain 22
IDBP-133265
a disintegrin and metallopeptidase domain 22
IDBP-249696
a disintegrin and metallopeptidase domain 22
IDBP-249698
a disintegrin and metallopeptidase domain 22
IDBP-249700
a disintegrin and metallopeptidase domain 22
IDBP-539916
a disintegrin and metallopeptidase domain 22
IDBP-790099
a disintegrin and metallopeptidase domain 22
IDBP-537948
a disintegrin and metallopeptidase domain 22
IDBP-536161
a disintegrin and metallopeptidase domain 22
IDBP-537202
a disintegrin and metallopeptidase domain 22
IDBP-537614
a disintegrin and metallopeptidase domain 22
IDBP-542727
a disintegrin and metallopeptidase domain 22
IDBP-539907
a disintegrin and metallopeptidase domain 22
IDBP-536717
a disintegrin and metallopeptidase domain 22
IDBP-532175
a disintegrin and metallopeptidase domain 22
IDBP-539060
a disintegrin and metallopeptidase domain 22
IDBP-538935
a disintegrin and metallopeptidase domain 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008277:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:8072352-8368160
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000050166 ENSMUSP00000055000
ENSMUST00000088761 ENSMUSP00000086139
ENSMUST00000088744 ENSMUSP00000086122
ENSMUST00000046838 ENSMUSP00000049120
ENSMUST00000115388 ENSMUSP00000111046
ENSMUST00000115386 ENSMUSP00000111044
ENSMUST00000115385 ENSMUSP00000111043
ENSMUST00000124121 ENSMUSP00000122652
ENSMUST00000144241 ENSMUSP00000138353
ENSMUST00000154935 ENSMUSP00000119409
ENSMUST00000139048 ENSMUSP00000116736
ENSMUST00000139841 ENSMUSP00000115775
ENSMUST00000153427 ENSMUSP00000120995
ENSMUST00000136524 ENSMUSP00000116422
ENSMUST00000153889 ENSMUSP00000123196
ENSMUST00000123168 ENSMUSP00000122758
ENSMUST00000130315 ENSMUSP00000121156
ENSMUST00000136808 ENSMUSP00000122426
ENSMUST00000126384 ENSMUSP00000118571
ENSMUST00000138652
ENSMUST00000143929
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0008344 adult locomotory behavior
GO:0014037 Schwann cell differentiation
GO:0022011 myelination in peripheral nervous system
GO:0042063 gliogenesis
Cellular Component
GO:0005576 extracellular region
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000008277
View Gene Order
ENSBTAG00000007136
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.275895 Mm.394078 Mm.447658 Mm.456949
RefSeq NM_001007220 NM_001007221 NM_001098225 XM_006503535 XM_006503537 XM_006503538 XM_006503539 XM_006503540 XM_006503541 XM_006503542
OMIM
CCDS CCDS19080 CCDS51411
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca