Version 5.4
Mus musculus Gene: Arfgef1
Summary
InnateDB Gene IDBG-133303.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arfgef1
Gene Name ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000067851
Encoded Proteins
IDBP-133305
ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
IDBP-532593
ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066777:
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:10137571-10232670
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000088615 ENSMUSP00000085986
ENSMUST00000142497
ENSMUST00000156563
ENSMUST00000128834
ENSMUST00000131556 ENSMUSP00000118805
ENSMUST00000187417
ENSMUST00000186813
ENSMUST00000186720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0017022 myosin binding
GO:0034237 protein kinase A regulatory subunit binding
Biological Process
GO:0007030 Golgi organization
GO:0010256 endomembrane system organization
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030837 negative regulation of actin filament polymerization
GO:0032012 regulation of ARF protein signal transduction
GO:0034259 negative regulation of Rho GTPase activity
GO:0043087 regulation of GTPase activity
GO:0090284 positive regulation of protein glycosylation in Golgi
GO:0090303 positive regulation of wound healing
GO:2000114 regulation of establishment of cell polarity
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0030532 small nuclear ribonucleoprotein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000066777
View Gene Order
ENSBTAG00000014691
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.229141 Mm.366703 Mm.410508 Mm.490565
RefSeq NM_001102430
OMIM
CCDS CCDS35512
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca