Version 5.4
Mus musculus Gene: Cbll1
Summary
InnateDB Gene IDBG-133313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cbll1
Gene Name Casitas B-lineage lymphoma-like 1
Synonyms AI467391; c-Cbl-like; Hakai
Species Mus musculus
Ensembl Gene ENSMUSG00000020659
Encoded Proteins
IDBP-133315
Casitas B-lineage lymphoma-like 1
IDBP-133317
Casitas B-lineage lymphoma-like 1
IDBP-133319
Casitas B-lineage lymphoma-like 1
IDBP-789365
Casitas B-lineage lymphoma-like 1
IDBP-789366
Casitas B-lineage lymphoma-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105879:
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:31484829-31499616
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000064240 ENSMUSP00000063266
ENSMUST00000101499 ENSMUSP00000099038
ENSMUST00000085487 ENSMUSP00000082616
ENSMUST00000185739 ENSMUSP00000141007
ENSMUST00000188326 ENSMUSP00000139809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
Biological Process
GO:0007162 negative regulation of cell adhesion
GO:0016337 single organismal cell-cell adhesion
GO:0016567 protein ubiquitination
GO:0030335 positive regulation of cell migration
GO:0045807 positive regulation of endocytosis
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105879
View Gene Order
ENSBTAG00000018348
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.273270 Mm.405506 Mm.475493 Mm.490990
RefSeq NM_001253847 NM_001253848 NM_134048 XM_006514936 XM_006514937 XM_006514938 XM_006514939 XM_006514940 XM_006514941 XM_006514942
OMIM
CCDS CCDS56834 CCDS56835
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca