Mus musculus Gene: Prkar2b | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-133755.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Prkar2b | ||||||||||||||||||||||
Gene Name | protein kinase, cAMP dependent regulatory, type II beta | ||||||||||||||||||||||
Synonyms | AI451071; AW061005; Pkarb2; PKARIIbeta; RII(beta) | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000002997 | ||||||||||||||||||||||
Encoded Proteins |
protein kinase, cAMP dependent regulatory, type II beta
protein kinase, cAMP dependent regulatory, type II beta
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005249:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:31958476-32061296 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Recruitment of mitotic centrosome proteins and complexes pathway
Innate Immune System pathway
G2/M Transition pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Cell Cycle, Mitotic pathway
Disease pathway
Hemostasis pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Hedgehog 'off' state pathway
Integration of energy metabolism pathway
Loss of Nlp from mitotic centrosomes pathway
Ca-dependent events pathway
Signaling by FGFR in disease pathway
DARPP-32 events pathway
PLC-gamma1 signalling pathway
PKA-mediated phosphorylation of CREB pathway
Cell Cycle pathway
Metabolism pathway
PKA activation in glucagon signalling pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Aquaporin-mediated transport pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
Factors involved in megakaryocyte development and platelet production pathway
Mitotic G2-G2/M phases pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Signaling by EGFR pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Phospholipase C-mediated cascade pathway
Transmembrane transport of small molecules pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Signalling by NGF pathway
Signaling by PDGF pathway
DAG and IP3 signaling pathway
Signaling by Hedgehog pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Calmodulin induced events pathway
Signal Transduction pathway
Signaling by FGFR pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
PKA activation pathway
Centrosome maturation pathway
DAP12 interactions pathway
DAP12 signaling pathway
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KEGG |
Insulin signaling pathway pathway
Apoptosis pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
PKA activation pathway
PKA-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Factors involved in megakaryocyte development and platelet production pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
PLC beta mediated events pathway
DARPP-32 events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
Integration of energy metabolism pathway
Signaling by FGFR in disease pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
Cell Cycle pathway
Immune System pathway
Centrosome maturation pathway
NGF signalling via TRKA from the plasma membrane pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Metabolism pathway
Ca-dependent events pathway
Aquaporin-mediated transport pathway
Disease pathway
Hemostasis pathway
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KEGG |
Apoptosis pathway
Insulin signaling pathway pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.25594 Mm.402547 Mm.490763 | ||||||||||||||||||||||
RefSeq | NM_011158 XM_006515014 XM_006515015 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS25869 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||