InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Parn

Summary

InnateDB Gene

IDBG-133815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Parn

Gene Name

poly(A)-specific ribonuclease (deadenylation nuclease)

Synonyms

1200003I18Rik; DAN

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022685

Encoded Proteins

IDBP-133817

poly(A)-specific ribonuclease (deadenylation nuclease)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140694:
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
The protein encoded by this gene is a 3\'-exoribonuclease, with similarity to the RNase D family of 3\'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:13537964-13668170

Strand

Reverse strand

Band

Transcripts

ENSMUST00000058884

ENSMUSP00000055969

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006402	mRNA catabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic