Version 5.4
Mus musculus Gene: Pik3cg
Summary
InnateDB Gene IDBG-133881.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pik3cg
Gene Name phosphoinositide-3-kinase, catalytic, gamma polypeptide
Synonyms 5830428L06Rik; p110gamma; PI3Kgamma
Species Mus musculus
Ensembl Gene ENSMUSG00000020573
Encoded Proteins
IDBP-133883
phosphoinositide-3-kinase, catalytic, gamma polypeptide
IDBP-133885
phosphoinositide-3-kinase, catalytic, gamma polypeptide
IDBP-539085
phosphoinositide-3-kinase, catalytic, gamma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25022365
Rab8a interacts with Pik3cg to regulate Akt signalling generated by surface Tlr4.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105851:
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq, Jul 2008]
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:32173473-32208659
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000053215 ENSMUSP00000062864
ENSMUST00000085469 ENSMUSP00000082596
ENSMUST00000156904 ENSMUSP00000123539
ENSMUST00000126814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0046875 ephrin receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0001525 angiogenesis
GO:0002376 immune system process
GO:0002675 positive regulation of acute inflammatory response
GO:0006468 protein phosphorylation
GO:0006897 endocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0010897 negative regulation of triglyceride catabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0032252 secretory granule localization
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0046854 phosphatidylinositol phosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0097284 hepatocyte apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005944 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105851
View Gene Order
ENSBTAG00000020848
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_198973
Synthesis of PIPs at the plasma membrane pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_188643
Phospholipid metabolism pathway
REACT_207835
G-protein beta:gamma signalling pathway
REACT_188257
Signal Transduction pathway
REACT_223974
G beta:gamma signalling through PI3Kgamma pathway
KEGG
mmu05213
Endometrial cancer pathway
mmu05211
Renal cell carcinoma pathway
mmu04012
ErbB signaling pathway pathway
mmu04930
Type II diabetes mellitus pathway
mmu04370
VEGF signaling pathway pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu05218
Melanoma pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05214
Glioma pathway
mmu04150
mTOR signaling pathway pathway
mmu05222
Small cell lung cancer pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04210
Apoptosis pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu00562
Inositol phosphate metabolism pathway
mmu05223
Non-small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05212
Pancreatic cancer pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu05200
Pathways in cancer pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
mmu05146
Amoebiasis pathway
mmu04380
Osteoclast differentiation pathway
mmu04973
Carbohydrate digestion and absorption pathway
mmu05145
Toxoplasmosis pathway
mmu05160
Hepatitis C pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_17
IL5 pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04150
mTOR signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa00562
Inositol phosphate metabolism pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04210
Apoptosis pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa05146
Amoebiasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
hsa04973
Carbohydrate digestion and absorption pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.101369 Mm.404878 Mm.416160 Mm.474070 Mm.487562
RefSeq NM_001146200 NM_001146201 NM_020272 XM_006515112
OMIM
CCDS CCDS25870
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca