InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plxna4

Summary

InnateDB Gene

IDBG-134005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plxna4

Gene Name

plexin A4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029765

Encoded Proteins

IDBP-250376

plexin A4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21098092

Plxna4 is a receptor protein and its expression in macrophages is required for optimal cytokine production upon Tlr stimulation. Plxna4 is a crucial component of sepsis-induced cytokine storm by activating Rac1, Mapk8 and Nfkb.

InnateDB Annotation from Orthologs

Summary

PMID 21098092

[Homo sapiens] PLXNA4 is a receptor protein and its expression in macrophages is required for optimal cytokine production upon TLR stimulation. PLXNA4 is a crucial component of sepsis-induced cytokine storm by activating RAC1, MAPK8 and NFKB.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000221866:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:32144268-32588192

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000115096

ENSMUSP00000110748

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity

Biological Process

GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0008045	motor neuron axon guidance
GO:0021602	cranial nerve morphogenesis
GO:0021610	facial nerve morphogenesis
GO:0021612	facial nerve structural organization
GO:0021615	glossopharyngeal nerve morphogenesis
GO:0021636	trigeminal nerve morphogenesis
GO:0021637	trigeminal nerve structural organization
GO:0021644	vagus nerve morphogenesis
GO:0021784	postganglionic parasympathetic nervous system development
GO:0021785	branchiomotor neuron axon guidance
GO:0021793	chemorepulsion of branchiomotor axon
GO:0021960	anterior commissure morphogenesis
GO:0045087	innate immune response (InnateDB)
GO:0048485	sympathetic nervous system development
GO:0048812	neuron projection morphogenesis
GO:0048841	regulation of axon extension involved in axon guidance
GO:0050923	regulation of negative chemotaxis
GO:0071526	semaphorin-plexin signaling pathway
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance