InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cep57

Summary

InnateDB Gene

IDBG-134181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cep57

Gene Name

centrosomal protein 57

Synonyms

3110002L15Rik; 4921510P06Rik; 4931428M20Rik; AI467480; mKIAA0092; Tsp57

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031922

Encoded Proteins

IDBP-134183

centrosomal protein 57

IDBP-537326

centrosomal protein 57

IDBP-534894

centrosomal protein 57

IDBP-534382

centrosomal protein 57

IDBP-538070

centrosomal protein 57

IDBP-540834

centrosomal protein 57

IDBP-540385

centrosomal protein 57

IDBP-537799

centrosomal protein 57

IDBP-532442

centrosomal protein 57

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166037:
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:13807792-13827107

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034398	ENSMUSP00000034398
ENSMUST00000142494	ENSMUSP00000114749
ENSMUST00000148086	ENSMUSP00000114665
ENSMUST00000147115	ENSMUSP00000116931
ENSMUST00000124883	ENSMUSP00000119081
ENSMUST00000134746	ENSMUSP00000116713
ENSMUST00000131425
ENSMUST00000150893	ENSMUSP00000115338
ENSMUST00000151878	ENSMUSP00000116847
ENSMUST00000148904
ENSMUST00000144484	ENSMUSP00000114940
ENSMUST00000124524

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0017134	fibroblast growth factor binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0007286	spermatid development
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0034453	microtubule anchoring
GO:0051260	protein homooligomerization