Version 5.4
Mus musculus Gene: Ube2j1
Summary
InnateDB Gene IDBG-134302.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2j1
Gene Name ubiquitin-conjugating enzyme E2J 1
Synonyms 0710008M05Rik; 1110030I22Rik; Ncube; NCUBE-1; Ncube1; Ubc6p
Species Mus musculus
Ensembl Gene ENSMUSG00000028277
Encoded Proteins
IDBP-134304
ubiquitin-conjugating enzyme E2, J1
IDBP-540544
ubiquitin-conjugating enzyme E2, J1
IDBP-536673
ubiquitin-conjugating enzyme E2, J1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198833:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:33031416-33052363
Strand Forward strand
Band A5
Transcripts
ENSMUST00000029944 ENSMUSP00000029944
ENSMUST00000124992 ENSMUSP00000118333
ENSMUST00000135924 ENSMUSP00000115757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0016567 protein ubiquitination
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198833
View Gene Order
ENSBTAG00000018436
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu05012
Parkinson's disease pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05012
Parkinson's disease pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.259095 Mm.474388
RefSeq NM_019586 XM_006538107
OMIM
CCDS CCDS18019
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca