Version 5.4
Homo sapiens Gene: ANO2
Summary
InnateDB Gene IDBG-13438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANO2
Gene Name anoctamin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000047617
Encoded Proteins
IDBP-13440
anoctamin 2
IDBP-62059
anoctamin 2
IDBP-598475
anoctamin 2
IDBP-596909
anoctamin 2
IDBP-808304
anoctamin 2, calcium activated chloride channel
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:5531869-5946232
Strand Reverse strand
Band p13.31
Transcripts
ENST00000327087 ENSP00000314048
ENST00000356134 ENSP00000348453
ENST00000536751
ENST00000541874
ENST00000545860 ENSP00000443813
ENST00000542326
ENST00000538154
ENST00000540543
ENST00000544988
ENST00000541487
ENST00000546188 ENSP00000440981
ENST00000612575 ENSP00000481449
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031513 nonmotile primary cilium
GO:0034707 chloride channel complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038115
View Gene Order
ENSBTAG00000012246
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9NQ90
TrEMBL Q69YW4
UniProt Splice Variant
Entrez Gene 57101
UniGene
RefSeq XM_006718989 XM_006718990 NM_001278596 NM_001278597 XM_006718988
HUGO HGNC:1183
OMIM 610109
CCDS CCDS44807
HPRD 11634
IMGT
EMBL AC006431 AC006560 AC137627 AJ272204 AK024010 AL137419 FJ384095
GenPept ACL36050 BAB14773 CAC01125 CAH10704
RNA Seq Atlas 57101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca